dr. Heil's seminar

Lunedì, 25 Giugno 2018 dalle ore 11:00 alle ore 12:00

Room 6302 PRC building

TITLE: Immunity induction by leaf extracts – DAMPs as the active principle

SPEAKER: Martin Heil, Lab. of Plant Ecology CINVESTAV – Irapuato, Irapuato, GTO, México 

NFofLAvr

ABSTRACT: Hundreds of studies found an enhanced immunity in plants after the application of plant or algal extracts. In search for the active principle, we discovered that leaf extracts induce immunity-related signalling cascades and phenotypic resistance in common bean (Phaseolus vulgaris) and lima bean (P. lunatus). This induction was species-specific, i.e., extracts from plants of the same cultivar, or species, elicited a stronger response than extracts from taxonomically distant sources. One factor that explains this highly specific 'damaged-self recognition' is the action of extracellular DNA (eDNA) as a damage-associated molecular pattern (DAMP). Fragments of eDNA or cytosolic DNA are well known triggers of inflammation and immunity in mammals. In bean, only eDNA from the same species, but not from the congeneric lima bean, induced the formation of ROS, the activation of MAPKs, and phenotypic resistance8. eDNA bears an as yet unexplored potential as a future plant vaccine.

HOST: Michele Perazzolli

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