Exploring the potential of apple dihydrochalcones ExPoApple2


Funding: Euroregione alpina Tirolo-Alto Adige-Trentino - Euregio Science Fund 2nd call

PI: Stefan Martens - Fondazione Edmund Mach

Timeframe: 01/07/2017 - 30/06/2020

Partners: Fondazione Edmund Mach (Trentino), Free University of Bozen‐Bolzano (South Tyrol), University of Innsbruck (Tyrol)

The apple tree (Malus sp.) is an agriculturally and economically important source of food and beverages. Especially the region Trentino-Alto Adige but also the “Genussregion Oberland” (in Tyrol) are well known for the important production of high quality apples. Fruits are high in various polyphenolic compounds with dihydrochalcones as characteristic bioactive compound of the genus Malus, with otherwise only limited distribution in higher plants. Dihydrochalcone derivatives like phloretin, trilobatin, phloridzin and sieboldin were detected in various apple genotypes or species and have been characterized as potent pharmaceuticals, nutraceuticals and sweeteners. The consortium of Foundazione Edmund Mach (BPN – Stefan Martens; coordinator), Freie Universtaet Bozen (Bioorganic Chemistry and Bio-Crystallography laboratory - Stefano Benini) and University of Innsbruck (Pharmaceutical Biology - Herrmann Stuppner) will explore the distribution, the biological pathway including functionality of involved proteins and new nutritional, cosmetical and pharmaceutical targets/applications of apple derived natural and biotechnological modified dihydrochalcones. Additional these results will enable new and innovative breeding strategies to enhance the value of apple fruits and apple derived products.

More info: Euregio website