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Claudio joined the Computational Biology Department under the supervision of Duccio Cavalieri from the 1st of July 2013.
Claudio achieved his master’s degree from the Department of Physics of the University of Pisa, and a PhD in Physics from the Scuola Normale Superiore of Pisa. He then joined the Center for Theoretical and Computational Materials Science of the National Institute of Standards and Technology in Washington and then he moved to the Physics Department of the Universita’ La Sapienza di Roma. In the year 2000 he joined the Systems Biology group of the Chiron Research Center in Siena as senior scientist. In 2008, after the acquisition of Chiron by Novartis Vaccines and Diagnostics he became Head of the Genomics laboratory, and in 2011 Head of the Genomics Unit. Since July 2013 Claudio is Group Leader of the Computational Metagenomics group of the FEM in San Michele all’Adige.
Claudio started his scientific career by studying the applications of the theory of stochastic processes to Electron Paramagnetic Resonance spectroscopy, in order to characterize the relaxation processes in liquids and other complex systems, like liquid crystals and polymers. Then, he moved to the study of the statistical mechanics of supercooled liquids and glasses. During his stay at NIST, he used molecular dynamics simulations to explore the dynamical properties of liquids on approaching the glass transition, a characteristic state of the matter that shares properties both of the liquid and of the solid state.
After joining Chiron, he started to work on the evolution of protein families, on comparative genomics of bacterial pathogens, and on vaccine target identification and characterization using the Reverse Vaccinology approach. With the increasing availability of whole genome sequences of bacterial species, he worked on the definition of the population structure of bacterial pathogens such asS. pneumoniae, N. meningitidis, Group B Streptococcus and Non-TypeableH. influenzae. Lately, he was involved in the development of molecular typing methods of bacterial species using Next Generation Sequencing data. In his new role in Fondazione Edmund Mach, Claudio Donati is working on new computational approaches for the analysis matagenomic data. Given his multidisciplinary background, the focus of the work of Claudio Donati is the application of innovative analysis techniques to the understanding of the equilibrium between the complex bacterial communities and the environment. In particular, Claudio Donati aims to understand the factors and interactions, including processes of horizontal gene transport that influence the evolution of bacterial genomes.
The current H-index of Claudio Donati is equal to 24, and his publications have been cited more than 4500 times (ref. google scholar ).
Top ten publications:
- H. Tettelin, V. Masignani, M. J. Cieslewicz, C. Donati, D. Medini, N.L. Ward, S.V. et al., "Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial pan-genome". Proc Natl Acad Sci U S A. 13950-5, 102 (2005). 711 citations
- W. Kob, C. Donati, S. Plimpton, P.Poole and S.C.Glotzer, "Dynamical Heterogeneities in a Supercooled Lennard-Jones Liquid" Phys. Rev. Lett. 79, 2827 (1997). 671 citations
- C. Donati, J.F. Douglas, W. Kob, S.J. Plimpton, P.H. Poole, S.C. Glotzer, "String-like cooperative motion in a supercooled liquid", Phys. Rev. Lett. 80, 2338 (1998). 667 citations
- C. Donati, S. C. Glotzer, P. H. Poole, W. Kob and S. J. Plimpton, “Spatial correlations of mobility and immobility in a glass-forming Lennard-Jones liquid”, Phys. Rev. E, 60, 3107 (1999). 384 citations
- D. Medini, C. Donati, H. Tettelin, V. Masignani, and R. Rappuoli. "The microbial pan-genome" Curr Opin Genet Dev. 589-94, 15 (2005). 325 citations
- C. Bennemann, C. Donati, J. Baschnagel and S. C. Glotzer, "Growing range of correlated motion in a polymer melt on cooling towards the glass transition'', Nature, 399, 246 (1999). 318 citations
- C. Donati, S. C. Glotzer and P. H. Poole, “Growing spatial correlation of particle displacements in a simulated liquid”, Phys.Rev.Lett. 82, 5064 (1999). 139 citations
- C. Donati, S. Franz, S. C. Glotzer and G. Parisi "Theory of non-linear susceptibility and correlation length in glasses and liquids" J. Non-Cryst. Solids 307-310, 215 (2002). 120 citations
- Bagnoli F, Moschioni M, Donati C., Dimitrovska V, Ferlenghi I, et al. A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J Bacteriol 190 (2008): 5480-5492. 96 citations
- Donati C., Hiller NL, Tettelin H, Muzzi A, Croucher NJ, Angiuoli SV, Oggioni M, Dunning Hotopp JC, Hu FZ, Riley DR, Covacci A, Mitchell TJ, Bentley SD, Kilian M, Ehrlich GD, Rappuoli R, Moxon ER, Masignani V. Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. Genome Biol. 2010; 11(10):R107. Epub 2010 Oct 29. 80 citations